DNA Traits · Sleep & rhythms
Snoring (TRAM1)
Whether people report snoring.
What the research found
In the cited research, the A allele at rs13251292 was associated with a lower tendency to report snoring in the studied cohorts.
- GG
- More often
- AG
- Middle
- AA
- Less often
- Evidence
- Genome-wide association in UK Biobank, replicated in the China Kadoorie Biobank
- Who was studied
- UK Biobank adults of white British ancestry; replication in Chinese adults
How common each genotype is
| Region | GGMore often | AGMiddle | AALess often |
|---|---|---|---|
| All regions2,504 people | 6% | 27% | 67% |
| Africa661 people | 1% | 20% | 79% |
| The Americas347 people | 7% | 33% | 59% |
| East Asia504 people | 1% | 15% | 84% |
| Europe503 people | 17% | 49% | 34% |
| South Asia489 people | 3% | 23% | 74% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- TRAM1 / LACTB2 region
- Marker
- rs13251292
- Location
- Chromosome 8 · GRCh37 71,474,355 · GRCh38 70,562,120
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- TRAM1 / LACTB2 region · rs13251292
- Location
- Chromosome 8 · GRCh37 71,474,355 · GRCh38 70,562,120
- Studied allele
- A
- Published statistic
- BOLT-LMM beta -0.00737 per A (SE 0.001067), P 4.3e-12; minor allele G 0.4145 (Table 2). China Kadoorie Biobank: beta -0.049 (SE 0.017) per A, P 0.005, minor allele frequency 0.071 (Zhu et al., 2024, Supplementary Data 12) (Table 2)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 138 / 685 / 1681 · Africa 7 / 134 / 520 · The Americas 26 / 115 / 206 · East Asia 6 / 75 / 423 · Europe 85 / 247 / 171 · South Asia 14 / 114 / 361
What it cannot tell you
Snoring was taken from a partner's or housemate's complaint, so people who sleep alone count as non-snorers.
Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank (Campos et al., 2020)More in Sleep & rhythms
- Morning preference association
- Snoring tendency association
- Sleep efficiency association
- Overnight sleep episodes association
- Sleep midpoint timing association
- Daytime napping association
- Daytime sleepiness association
- Difficulty sleeping association
- Morning preference (RGS16)
- Morning preference (AK5)
- Snoring (POC5)
- Daytime napping (TLE4)
- Daytime napping (STK32A)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.