DNA Traits · Sleep & rhythms
Sleep efficiency association
The share of time in bed that is spent asleep, measured with a wrist tracker.
What the research found
In the cited research, the G allele at rs113851554 was associated with higher accelerometer-estimated sleep efficiency in the studied cohorts.
- TT
- Lower average
- GT
- Middle
- GG
- Higher average
What the study found
In the study, each copy went with higher sleep efficiency from a wrist tracker, the share of the night's sleep window spent asleep on average.
- Evidence
- Genome-wide association using seven-day wrist accelerometry
- Who was studied
- European-ancestry UK Biobank adults with seven-day wrist accelerometer measurements
How common each genotype is
| Region | TTLower average | GTMiddle | GGHigher average |
|---|---|---|---|
| All regions2,504 people | <1% | 4% | 96% |
| Africa661 people | Not seen | <1% | >99% |
| The Americas347 people | Not seen | 4% | 96% |
| East Asia504 people | Not seen | Not seen | All |
| Europe503 people | <1% | 10% | 90% |
| South Asia489 people | Not seen | 6% | 94% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 100%34 of 34 copies read |
|---|---|
| First farmers6500 to 3000 BC | 99%209 of 212 copies read |
| Bronze Age3000 to 1200 BC | 98%160 of 164 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 95%449 of 475 copies read |
| Middle AgesAD 600 to 1500 | 96%439 of 457 copies read |
| Today1000 Genomes | 95%953 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- Not read
- Vindija Neanderthal
- Not read
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- Not read
The marker
- Gene or region
- MEIS1 region
- Marker
- rs113851554
- Location
- Chromosome 2 · GRCh37 66,750,564 · GRCh38 66,523,432
- Letters studied
- G and T, with G as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- MEIS1 region · rs113851554
- Location
- Chromosome 2 · GRCh37 66,750,564 · GRCh38 66,523,432
- Studied allele
- G
- Published statistic
- beta 0.101 SD per G allele (SE 0.011), P 5e-22; G frequency 0.943; SD units of the inverse-normal transformed trait; 0.1 SD per copy (Table 3 (beta, SE, P, effect allele frequency); Methods, association testing paragraph (results reported on the inverse-normal scale))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 2 / 97 / 2405 · Africa 0 / 6 / 655 · The Americas 0 / 15 / 332 · East Asia 0 / 0 / 504 · Europe 2 / 49 / 452 · South Asia 0 / 27 / 462
What it cannot tell you
Sleep efficiency was estimated from wrist movement, rather than measured with clinical sleep recordings. Periodic limb movements associated with restless legs syndrome may affect the wrist estimate, so this signal may not reflect sleep efficiency alone. This marker does not estimate your sleep efficiency, is not a test for a sleep disorder and does not measure recovery. It shares a marker with the insomnia-symptom card; these are two study outcomes, not independent genetic findings. Only the studied G/T allele pair is interpreted.
Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour (Jones et al., 2019)More in Sleep & rhythms
- Morning preference association
- Snoring tendency association
- Overnight sleep episodes association
- Sleep midpoint timing association
- Daytime napping association
- Daytime sleepiness association
- Difficulty sleeping association
- Morning preference (RGS16)
- Morning preference (AK5)
- Snoring (POC5)
- Snoring (TRAM1)
- Daytime napping (TLE4)
- Daytime napping (STK32A)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.