DNA Traits · Sleep & rhythms
Difficulty sleeping association
Trouble falling asleep or staying asleep, as people reported it.
What the research found
In the cited research, the T allele at rs113851554 was associated with more frequent difficulty falling asleep or staying asleep in the studied cohorts.
- GG
- Less often
- GT
- Middle
- TT
- More often
- Evidence
- Replicated association with reported insomnia symptoms
- Who was studied
- European-ancestry UK Biobank participants, with independent HUNT and Partners Biobank replication
How common each genotype is
| Region | GGLess often | GTMiddle | TTMore often |
|---|---|---|---|
| All regions2,504 people | 96% | 4% | <1% |
| Africa661 people | >99% | <1% | Not seen |
| The Americas347 people | 96% | 4% | Not seen |
| East Asia504 people | All | Not seen | Not seen |
| Europe503 people | 90% | 10% | <1% |
| South Asia489 people | 94% | 6% | Not seen |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 0%0 of 34 copies read |
|---|---|
| First farmers6500 to 3000 BC | 1%3 of 212 copies read |
| Bronze Age3000 to 1200 BC | 2%4 of 164 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 5%26 of 475 copies read |
| Middle AgesAD 600 to 1500 | 4%18 of 457 copies read |
| Today1000 Genomes | 5%53 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- Not read
- Vindija Neanderthal
- Not read
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- Not read
The marker
- Gene or region
- MEIS1
- Marker
- rs113851554
- Location
- Chromosome 2 · GRCh37 66,750,564 · GRCh38 66,523,432
- Letters studied
- G and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- MEIS1 · rs113851554
- Location
- Chromosome 2 · GRCh37 66,750,564 · GRCh38 66,523,432
- Studied allele
- T
- Published statistic
- OR 1.19 per T allele (95% CI 1.15 to 1.23), P 1.5e-21; MEIS1 replication also reported in HUNT (14,923 cases, 47,610 controls) and Partners Biobank (2,217 cases, 14,240 controls); BUHMBOX with 20 restless-legs SNPs P 4.09e-6 (heterogeneity) (Results)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 2405 / 97 / 2 · Africa 655 / 6 / 0 · The Americas 332 / 15 / 0 · East Asia 504 / 0 / 0 · Europe 452 / 49 / 2 · South Asia 462 / 27 / 0
What it cannot tell you
This is an association with reported insomnia symptoms; it is not a test for insomnia or a prediction that you will develop it. Part of the signal may reflect restless legs symptoms in people reporting sleep difficulties; the marker is not specific to insomnia. The marker is also used for the separate sleep efficiency association; these are related observations, not two independent genetic signals. It is not a test for restless legs syndrome and does not recommend treatment. Only the studied G/T allele pair is interpreted; A calls are unsupported by this association.
Biological and clinical insights from genetics of insomnia symptoms (Lane et al., 2019)More in Sleep & rhythms
- Morning preference association
- Snoring tendency association
- Sleep efficiency association
- Overnight sleep episodes association
- Sleep midpoint timing association
- Daytime napping association
- Daytime sleepiness association
- Morning preference (RGS16)
- Morning preference (AK5)
- Snoring (POC5)
- Snoring (TRAM1)
- Daytime napping (TLE4)
- Daytime napping (STK32A)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.