Evidence · Replicated

What the research found

In the cited research, the T allele at rs887829 was associated with higher total serum bilirubin concentrations in the studied cohorts.

CC: Lower average
CT: Middle
TT: Higher average

Strong effect

What the study found

In the study, each copy went with higher bilirubin in the blood on average.

Danish children and adolescents (population sample and an obesity clinic, HOLBAEK Study) · 3,350 people · Abstract and Results (GWAS paragraph with Figure 3)Genetics of Plasma Bilirubin and Associations between Bilirubin and Cardiometabolic Risk Profiles in Danish Children and Adolescents (Ullah et al., 2023)

Evidence: Replicated genome-wide association
Who was studied: European-ancestry adults; Danish children and adolescents for the figure

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	CCLower average	CTMiddle	TTHigher average
All regions2,504 people	43%	43%	14%
Africa661 people	24%	53%	23%
The Americas347 people	37%	49%	13%
East Asia504 people	76%	22%	2%
Europe503 people	49%	42%	9%
South Asia489 people	31%	50%	19%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	20%9 of 46 copies read
First farmers6500 to 3000 BC	33%198 of 594 copies read
Bronze Age3000 to 1200 BC	33%160 of 483 copies read
Iron Age and Antiquity1200 BC to AD 600	29%214 of 727 copies read
Middle AgesAD 600 to 1500	30%145 of 486 copies read
Today1000 Genomes	30%300 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: No copies
Chagyrskaya Neanderthal: No copies
Denisovan: No copies

Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs887829

The marker

Gene or region: UGT1A1
Marker: rs887829
Location: Chromosome 2 · GRCh37 234,668,570 · GRCh38 233,759,924
Letters studied: C and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: UGT1A1 · rs887829
Location: Chromosome 2 · GRCh37 234,668,570 · GRCh38 233,759,924
Studied allele: T
Published statistic: Ullah 2023: rs887829 T beta 0.78 SD per allele, P 2.9e-247, about 25% of variance (Abstract, Results). Johnson 2009: rs6742078 (perfect LD with rs887829 in CEU) beta +0.239, +0.230, +0.238 on log bilirubin per T in FHS, RS, AGES, combined P < 5e-324, meta +0.234 (SE 0.005), N 9,464 (Tables 1 and 3); 0.78 SD per copy (Abstract and Results (GWAS paragraph with Figure 3))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1073 / 1089 / 342 · Africa 161 / 348 / 152 · The Americas 130 / 171 / 46 · East Asia 382 / 113 / 9 · Europe 247 / 212 / 44 · South Asia 153 / 245 / 91

See this card in the sample report

Limits

What it cannot tell you

The marker stands in for the UGT1A1*28 promoter repeat, which a DNA file does not read directly. The per-copy figure comes from Danish children and adolescents.

Genome-wide association meta-analysis for total serum bilirubin levels (Johnson et al., 2009)

The same topic

More in Nutrition & metabolism

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