Evidence · Replicated

What the research found

In the cited research, the T allele at rs11144134 was associated with lower serum magnesium concentrations in the studied cohorts.

CC: Higher average
CT: Middle
TT: Lower average

Slight effect

What the study found

In the study, each copy went with serum magnesium about 0.01 mmol/L lower on average.

European-ancestry adults (CHARGE discovery cohorts and four replication cohorts) · Table 2

Evidence: Genome-wide association with independent replication
Who was studied: European-ancestry discovery and replication cohorts

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	CCHigher average	CTMiddle	TTLower average
All regions2,504 people	<1%	6%	93%
Africa661 people	Not seen	2%	98%
The Americas347 people	<1%	15%	84%
East Asia504 people	Not seen	<1%	>99%
Europe503 people	<1%	14%	85%
South Asia489 people	Not seen	5%	95%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	84%32 of 38 copies read
First farmers6500 to 3000 BC	86%368 of 427 copies read
Bronze Age3000 to 1200 BC	89%286 of 323 copies read
Iron Age and Antiquity1200 BC to AD 600	91%397 of 437 copies read
Middle AgesAD 600 to 1500	91%356 of 390 copies read
Today1000 Genomes	92%929 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: 2 copies
Vindija Neanderthal: 2 copies
Chagyrskaya Neanderthal: 2 copies
Denisovan: 2 copies

Neanderthals and Denisovans carried this letter too: it is the older of the two.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs11144134

The marker

Gene or region: TRPM6
Marker: rs11144134
Location: Chromosome 9 · GRCh37 77,499,796 · GRCh38 74,884,880
Letters studied: C and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: TRPM6 · rs11144134
Location: Chromosome 9 · GRCh37 77,499,796 · GRCh38 74,884,880
Studied allele: T
Published statistic: beta -0.011 mmol/L per T allele (SE 0.001), P 8.21e-15, 0.23% of variance, combined discovery (15,366) and replication (8,463) (Table 2); OR 1.20 (95% CI 1.00 to 1.44) per T allele for magnesium below 0.7 mmol/L (Table 3) (Table 2)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 6 / 158 / 2340 · Africa 0 / 12 / 649 · The Americas 2 / 53 / 292 · East Asia 0 / 1 / 503 · Europe 4 / 69 / 430 · South Asia 0 / 23 / 466

See this card in the sample report

Limits

What it cannot tell you

The common marker explains only a small part of serum magnesium variation. It is separate from rare TRPM6 mutations that cause inherited magnesium disorders, does not measure total-body magnesium and is not a test for such a disorder. It cannot tell you a current magnesium level, is not a test for deficiency and cannot choose a diet, supplement or dose.

Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels (Meyer et al., 2010)

The same topic

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