Evidence · Replicated

What the research found

In the cited research, the C allele at rs10882272 was associated with lower circulating retinol, a form of vitamin A, in the studied cohorts.

TT: Higher average
CT: Middle
CC: Lower average

Slight effect

What the study found

In the study, each copy went with serum retinol about 3% lower on average.

European-ancestry men (ATBC, PLCO) and women and men (Nurses' Health Study, InCHIANTI) · Results (relative difference per copy from the overall meta-analysis) and Table 1

Evidence: Genome-wide association with independent replication
Who was studied: European-ancestry male discovery cohorts and female and male replication cohorts

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	TTHigher average	CTMiddle	CCLower average
All regions2,504 people	41%	40%	19%
Africa661 people	15%	41%	44%
The Americas347 people	51%	41%	8%
East Asia504 people	81%	18%	2%
Europe503 people	39%	46%	15%
South Asia489 people	30%	56%	14%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	4%1 of 26 copies read
First farmers6500 to 3000 BC	41%130 of 319 copies read
Bronze Age3000 to 1200 BC	44%101 of 230 copies read
Iron Age and Antiquity1200 BC to AD 600	38%142 of 373 copies read
Middle AgesAD 600 to 1500	36%110 of 304 copies read
Today1000 Genomes	38%383 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: 2 copies
Vindija Neanderthal: 2 copies
Chagyrskaya Neanderthal: 2 copies
Denisovan: 2 copies

Neanderthals and Denisovans carried this letter too: it is the older of the two.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs10882272

The marker

Gene or region: RBP4 region
Marker: rs10882272
Location: Chromosome 10 · GRCh37 95,348,182 · GRCh38 93,588,425
Letters studied: C and T, with C as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: RBP4 region · rs10882272
Location: Chromosome 10 · GRCh37 95,348,182 · GRCh38 93,588,425
Studied allele: C
Published statistic: beta -0.03 (SE 0.004) in natural-log retinol per C allele, overall P 6.51e-15, heterogeneity P 0.67; discovery -0.03 (SE 0.005), P 6.04e-12; replication -0.02 (SE 0.006), P 9.49e-5; Table 1 (Results (relative difference per copy from the overall meta-analysis) and Table 1)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1021 / 1014 / 469 · Africa 97 / 274 / 290 · The Americas 177 / 141 / 29 · East Asia 406 / 90 / 8 · Europe 195 / 233 / 75 · South Asia 146 / 276 / 67

See this card in the sample report

Limits

What it cannot tell you

Retinol is one form of vitamin A. This association does not measure carotenoid conversion, vision, vitamin A requirements or total vitamin A stores, and it cannot be applied to every vitamin A compound. It cannot tell you a current retinol level, is not a test for deficiency and cannot choose a diet, supplement or dose.

Genome-wide association study of circulating retinol levels (Mondul et al., 2011)

The same topic

More in Nutrition & metabolism

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