Evidence · Replicated

What the research found

In the cited research, the T allele at rs1801725 was associated with higher albumin-adjusted serum calcium concentrations in the studied cohorts.

GG: Lower average
GT: Middle
TT: Higher average

Modest effect

What the study found

In the study, each copy went with albumin-adjusted serum calcium about 0.02 mmol/L higher on average.

European and Indian Asian adults (CoLaus, LOLIPOP, InCHIANTI, BLSA) · 12,865 people · Results paragraph after Table 2

Evidence: Genome-wide association with independent replication
Who was studied: European and Indian Asian discovery cohorts with Icelandic replication

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	GGLower average	GTMiddle	TTHigher average
All regions2,504 people	83%	16%	2%
Africa661 people	98%	2%	Not seen
The Americas347 people	80%	18%	1%
East Asia504 people	93%	7%	<1%
Europe503 people	72%	26%	1%
South Asia489 people	64%	30%	6%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	2%3 of 121 copies read
First farmers6500 to 3000 BC	11%144 of 1,282 copies read
Bronze Age3000 to 1200 BC	13%164 of 1,249 copies read
Iron Age and Antiquity1200 BC to AD 600	12%222 of 1,823 copies read
Middle AgesAD 600 to 1500	13%211 of 1,567 copies read
Today1000 Genomes	15%146 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: No copies
Chagyrskaya Neanderthal: No copies
Denisovan: No copies

Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs1801725

The marker

Gene or region: CASR
Marker: rs1801725
Location: Chromosome 3 · GRCh37 122,003,757 · GRCh38 122,284,910
Letters studied: G and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: CASR · rs1801725
Location: Chromosome 3 · GRCh37 122,003,757 · GRCh38 122,284,910
Studied allele: T
Published statistic: beta 3.61e-3 log10 mmol/L per T allele (95% CI 3.06e-3 to 4.16e-3), P 6.29e-37, R² 0.0126 (Table 3); Icelandic replication P 1.02e-4 (Results) (Results paragraph after Table 2)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 2072 / 392 / 40 · Africa 648 / 13 / 0 · The Americas 278 / 64 / 5 · East Asia 468 / 35 / 1 · Europe 364 / 132 / 7 · South Asia 314 / 148 / 27

See this card in the sample report

Limits

What it cannot tell you

Serum calcium is tightly regulated. This association does not measure calcium intake, calcium absorption or bone strength, and it is not a test for a calcium-regulation disorder. Only the studied G/T allele pair is interpreted. It cannot tell you a current calcium level, is not a test for deficiency and cannot choose a diet, supplement or dose.

Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene (Kapur et al., 2010)

The same topic

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