DNA Traits · Nutrition & metabolism
Transferrin level
The blood level of transferrin, the protein that carries iron in the blood.
What the research found
In the cited research, the T allele at rs8177240 was associated with lower serum transferrin concentrations in the studied cohorts.
- GG
- Higher average
- GT
- Middle
- TT
- Lower average
What the study found
In the study, each copy went with lower serum transferrin on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry adults from the Genetics of Iron Status Consortium
How common each genotype is
| Region | GGHigher average | GTMiddle | TTLower average |
|---|---|---|---|
| All regions2,504 people | 12% | 40% | 47% |
| Africa661 people | 1% | 21% | 77% |
| The Americas347 people | 17% | 45% | 38% |
| East Asia504 people | 19% | 48% | 33% |
| Europe503 people | 12% | 46% | 42% |
| South Asia489 people | 17% | 49% | 34% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- TF
- Marker
- rs8177240
- Location
- Chromosome 3 · GRCh37 133,477,701 · GRCh38 133,758,857
- Letters studied
- G and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- TF · rs8177240
- Location
- Chromosome 3 · GRCh37 133,477,701 · GRCh38 133,758,857
- Studied allele
- T
- Published statistic
- Transferrin: discovery -0.423 SD per T (SE 0.011), P 3.82e-340, N 23,986; D+R -0.380 (0.007), P 3.29e-615, N 48,972. Same allele: iron D+R -0.066, P 6.65e-20; transferrin saturation D+R +0.100, P 7.24e-38; ferritin D+R +0.021, P 0.0039 (Table 1); 0.38 SD per copy (Table 1 (D+R row))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 309 / 1012 / 1183 · Africa 9 / 142 / 510 · The Americas 58 / 157 / 132 · East Asia 96 / 244 / 164 · Europe 61 / 230 / 212 · South Asia 85 / 239 / 165
What it cannot tell you
Transferrin is the carrier protein, not iron itself; this marker moves transferrin far more than serum iron.
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis (Benyamin et al., 2014)More in Nutrition & metabolism
- Vitamin D concentration association
- Vitamin B6 concentration association
- Vitamin B12 concentration association
- Folate concentration association
- Retinol concentration association
- Alpha-tocopherol concentration association
- Serum iron concentration association
- Calcium concentration association
- Magnesium concentration association
- Blood selenium association
- Coffee intake
- Coffee intake
- Carbohydrate and protein intake
- Coffee intake
- Coffee intake
- Coffee intake
- Tea intake
- Carbohydrate and protein intake
- Bitter drinks intake
- Fatty acid conversion
- Beta-carotene level
- Uric acid level
- Vitamin D level, CYP2R1 marker
- Bilirubin level
- Vitamin D level, DHCR7 marker
- Uric acid level, ABCG2 marker
- Red cell zinc level
- Vitamin B12 level, CUBN marker
- Vitamin B12 level, TCN1 marker
- Magnesium level, DCDC5 marker
- Morning cortisol level
- TSH level
- Iron level, TFR2 marker
- Omega-3 DHA share
- Calcium level, CYP24A1 marker
- Bilirubin level, SLCO1B3 marker
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.