Evidence · Not yet replicated

What the research found

In the cited research, the T allele at rs2108622 was associated with higher circulating alpha-tocopherol, one form of vitamin E, in the studied cohorts.

CC: Lower average
CT: Middle
TT: Higher average

Slight effect

What the study found

In the study, the average alpha-tocopherol in the blood, by genotype:

CCNo copy: 11.8 mg/L
CTOne copy: 12.1 mg/L
TTTwo copies: 12.7 mg/L

Finnish male smokers aged 50 to 69 (ATBC study) · 4,014 people · Table 2 (ATBC row)

Evidence: Genome-wide association with nominal support in independent cohorts
Who was studied: Finnish male smokers in ATBC, with nominal support in US PLCO men and NHS women

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	CCLower average	CTMiddle	TTHigher average
All regions2,504 people	60%	32%	8%
Africa661 people	85%	14%	1%
The Americas347 people	58%	37%	5%
East Asia504 people	63%	32%	5%
Europe503 people	52%	38%	10%
South Asia489 people	36%	46%	18%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	58%26 of 45 copies read
First farmers6500 to 3000 BC	41%224 of 552 copies read
Bronze Age3000 to 1200 BC	39%163 of 416 copies read
Iron Age and Antiquity1200 BC to AD 600	32%206 of 643 copies read
Middle AgesAD 600 to 1500	32%120 of 374 copies read
Today1000 Genomes	29%292 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: Not read
Chagyrskaya Neanderthal: Not read
Denisovan: No copies

Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs2108622

The marker

Gene or region: CYP4F2
Marker: rs2108622
Location: Chromosome 19 · GRCh37 15,990,431 · GRCh38 15,879,621
Letters studied: C and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: CYP4F2 · rs2108622
Location: Chromosome 19 · GRCh37 15,990,431 · GRCh38 15,879,621
Studied allele: T
Published statistic: beta 0.04 (SE 0.01) per T allele on the log scale, P 1.7e-8 (ATBC); PLCO 0.05 (SE 0.02), P 0.018; NHS 0.02 (SE 0.01), P 0.027; combined 0.03 (SE 0.01), P 1.4e-10; Table 2 (Table 2 (ATBC row))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1510 / 802 / 192 · Africa 559 / 95 / 7 · The Americas 201 / 127 / 19 · East Asia 315 / 162 / 27 · Europe 261 / 192 / 50 · South Asia 174 / 226 / 89

See this card in the sample report

Limits

What it cannot tell you

The studied trait was alpha-tocopherol, not every form of vitamin E or a general antioxidant capacity. Discovery was in Finnish male smokers; the independent follow-up cohorts provided nominal support with modest effects. This card does not predict supplement response, vitamin K status or medication dosing. Only the studied C/T allele pair is interpreted. It cannot tell you a current vitamin E level, is not a test for deficiency and cannot choose a diet, supplement or dose.

Genome-wide association study identifies common variants associated with circulating vitamin E levels (Major et al., 2011)

The same topic

More in Nutrition & metabolism

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