Evidence · Replicated

What the research found

In the cited research, the T allele at rs734553 was associated with higher serum uric acid concentrations in the studied cohorts.

GG: Lower average
GT: Middle
TT: Higher average

Modest effect

What the study found

In the study, each copy went with higher uric acid in the blood on average.

European-ancestry adults in fourteen population cohorts · 27,817 people · Table 1 (All individuals columns) and footnote

Evidence: Genome-wide meta-analysis across cohorts, replicated in later studies
Who was studied: European-ancestry adults in fourteen cohorts

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	GGLower average	GTMiddle	TTHigher average
All regions2,504 people	14%	34%	52%
Africa661 people	34%	47%	19%
The Americas347 people	19%	45%	36%
East Asia504 people	Not seen	3%	97%
Europe503 people	6%	38%	57%
South Asia489 people	5%	36%	59%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	76%82 of 108 copies read
First farmers6500 to 3000 BC	70%784 of 1,118 copies read
Bronze Age3000 to 1200 BC	71%801 of 1,122 copies read
Iron Age and Antiquity1200 BC to AD 600	74%1,316 of 1,774 copies read
Middle AgesAD 600 to 1500	77%1,175 of 1,530 copies read
Today1000 Genomes	76%760 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: No copies
Chagyrskaya Neanderthal: No copies
Denisovan: No copies

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs734553

The marker

Gene or region: SLC2A9
Marker: rs734553
Location: Chromosome 4 · GRCh37 9,923,004 · GRCh38 9,921,380
Letters studied: G and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: SLC2A9 · rs734553
Location: Chromosome 4 · GRCh37 9,923,004 · GRCh38 9,921,380
Studied allele: T
Published statistic: beta 0.315 per T on Z-scores of uric acid (95% CI 0.294 to 0.335), P 5.22e-201, N 27,817, effect allele frequency 76.81%, 3.53% explained variability (Table 1); men 0.220, women 0.397, difference P 3.8e-17 (Table 2); 0.32 SD per copy (Table 1 (All individuals columns) and footnote)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 339 / 851 / 1314 · Africa 223 / 311 / 127 · The Americas 65 / 157 / 125 · East Asia 0 / 17 / 487 · Europe 28 / 190 / 285 · South Asia 23 / 176 / 290

See this card in the sample report

Limits

What it cannot tell you

In the studied cohorts the association was about twice as large in women as in men. It concerns the blood level only.

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations (Kolz et al., 2009)

The same topic

More in Nutrition & metabolism

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