DNA Traits · Nutrition & metabolism
Morning cortisol level
The morning blood level of cortisol, a hormone made by the adrenal glands.
What the research found
In the cited research, the T allele at rs9989237 was associated with higher morning plasma cortisol concentrations in the studied cohorts.
- CC
- Lower average
- CT
- Middle
- TT
- Higher average
What the study found
In the study, each copy went with higher morning cortisol in the blood on average.
- Evidence
- Genome-wide meta-analysis across cohorts with an independent later replication
- Who was studied
- European-ancestry adults in the CORNET consortium
How common each genotype is
| Region | CCLower average | CTMiddle | TTHigher average |
|---|---|---|---|
| All regions2,504 people | 52% | 38% | 11% |
| Africa661 people | 61% | 34% | 5% |
| The Americas347 people | 75% | 23% | 2% |
| East Asia504 people | 32% | 49% | 19% |
| Europe503 people | 63% | 32% | 4% |
| South Asia489 people | 30% | 47% | 22% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- SERPINA6 / SERPINA1 region
- Marker
- rs9989237
- Location
- Chromosome 14 · GRCh37 94,795,202 · GRCh38 94,328,865
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- SERPINA6 / SERPINA1 region · rs9989237
- Location
- Chromosome 14 · GRCh37 94,795,202 · GRCh38 94,328,865
- Studied allele
- T
- Published statistic
- Per minor allele +0.11 cortisol z-score, P 2.2e-19, effect allele frequency 0.22, 0.13% of variance, N 25,314 (Results). Pott 2019 (LIFE-Adult and LIFE-Heart, independent): T +0.040, P 6e-9 (GWAS Catalog GCST008882). Chan 2024 meta-analysis (includes CORNET): T +0.091, P 1e-26; 0.11 SD per copy (Results (genome-wide association meta-analysis paragraph))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1294 / 944 / 266 · Africa 404 / 224 / 33 · The Americas 260 / 81 / 6 · East Asia 162 / 245 / 97 · Europe 319 / 162 / 22 · South Asia 149 / 232 / 108
What it cannot tell you
The measure was total morning cortisol, most of it bound to the carrier protein this region encodes, so it is not a measure of free cortisol.
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease (Crawford et al., 2021)More in Nutrition & metabolism
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- Folate concentration association
- Retinol concentration association
- Alpha-tocopherol concentration association
- Serum iron concentration association
- Calcium concentration association
- Magnesium concentration association
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- Coffee intake
- Coffee intake
- Carbohydrate and protein intake
- Coffee intake
- Coffee intake
- Coffee intake
- Tea intake
- Carbohydrate and protein intake
- Bitter drinks intake
- Fatty acid conversion
- Beta-carotene level
- Uric acid level
- Vitamin D level, CYP2R1 marker
- Bilirubin level
- Vitamin D level, DHCR7 marker
- Uric acid level, ABCG2 marker
- Red cell zinc level
- Vitamin B12 level, CUBN marker
- Vitamin B12 level, TCN1 marker
- Magnesium level, DCDC5 marker
- Transferrin level
- TSH level
- Iron level, TFR2 marker
- Omega-3 DHA share
- Calcium level, CYP24A1 marker
- Bilirubin level, SLCO1B3 marker
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.