Evidence · Not yet replicated

What the research found

In the cited research, the G allele at rs3827760 was associated with less chin protrusion in the studied cohort.

AA: More forward
AG: Middle
GG: Less forward

Modest effect

Evidence: Discovery GWAS of quantitative facial geometry
Who was studied: Admixed Latin American CANDELA participants from Brazil, Chile, Colombia, Mexico and Peru

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	AAMore forward	AGMiddle	GGLess forward
All regions2,504 people	71%	10%	19%
Africa661 people	>99%	<1%	<1%
The Americas347 people	43%	35%	22%
East Asia504 people	2%	21%	77%
Europe503 people	98%	2%	Not seen
South Asia489 people	97%	3%	Not seen

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	0%0 of 66 copies read
First farmers6500 to 3000 BC	1%7 of 1,022 copies read
Bronze Age3000 to 1200 BC	2%18 of 967 copies read
Iron Age and Antiquity1200 BC to AD 600	2%24 of 1,160 copies read
Middle AgesAD 600 to 1500	12%73 of 602 copies read
Today1000 Genomes	1%11 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: No copies
Chagyrskaya Neanderthal: No copies
Denisovan: No copies

Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs3827760

The marker

Gene or region: EDAR
Marker: rs3827760
Location: Chromosome 2 · GRCh37 109,513,601 · GRCh38 108,897,145
Letters studied: A and G, with G as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: EDAR · rs3827760
Location: Chromosome 2 · GRCh37 109,513,601 · GRCh38 108,897,145
Studied allele: G
Published statistic: effect -7.6e-3 per G allele (EDAR 370A) on a Procrustes-adjusted 3D chin protrusion measure, P 4e-10, 1.32% of variance, n 2,955 (Table 2) (Table 2)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1788 / 252 / 464 · Africa 658 / 2 / 1 · The Americas 150 / 122 / 75 · East Asia 12 / 104 / 388 · Europe 492 / 11 / 0 · South Asia 476 / 13 / 0

See this card in the sample report

Limits

What it cannot tell you

This small marker association concerns measured facial geometry in the research sample. It does not reconstruct your face, classify attractiveness or calculate a facial measurement. This card shares an EDAR marker with the core hair-thickness card; these are distinct studied outcomes, not independent signals. Only the studied A/G allele pair is interpreted.

A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation (Adhikari et al., 2016)

The same topic

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