Evidence · Replicated

What the research found

In the cited research, the T allele at rs17640804 was associated with smaller nose wing breadth in the studied cohorts.

CC: Broader
CT: Middle
TT: Narrower

Slight effect

What the study found

In the study, each copy went with nose wing breadth rating from photos, on a three level scale where higher is broader about 0.07 points lower on average.

Admixed Latin American CANDELA participants from Brazil, Chile, Colombia, Mexico and Peru · 5,958 people · Table 1; Supplementary Figure 1 (three levels coded 0 to 2)

Evidence: Genome-wide association with independent replication
Who was studied: Admixed Latin American CANDELA participants from Brazil, Chile, Colombia, Mexico and Peru

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	CCBroader	CTMiddle	TTNarrower
All regions2,504 people	6%	31%	63%
Africa661 people	4%	34%	62%
The Americas347 people	21%	44%	35%
East Asia504 people	1%	13%	86%
Europe503 people	4%	35%	61%
South Asia489 people	3%	31%	66%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	82%41 of 50 copies read
First farmers6500 to 3000 BC	75%540 of 723 copies read
Bronze Age3000 to 1200 BC	72%454 of 631 copies read
Iron Age and Antiquity1200 BC to AD 600	73%611 of 834 copies read
Middle AgesAD 600 to 1500	79%406 of 515 copies read
Today1000 Genomes	78%786 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: No copies
Chagyrskaya Neanderthal: No copies
Denisovan: No copies

Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs17640804

The marker

Gene or region: GLI3 region
Marker: rs17640804
Location: Chromosome 7 · GRCh37 42,131,390 · GRCh38 42,091,791
Letters studied: C and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: GLI3 region · rs17640804
Location: Chromosome 7 · GRCh37 42,131,390 · GRCh38 42,091,791
Studied allele: T
Published statistic: effect -0.065 per T allele on the ordinal rating, P 9e-9, 0.62% of variance, n 5,958; independent replication P 6e-3 in 501 people (Table 1); quantitative follow-up effect -4.9e-4, P 5e-10, 1.15% of variance, n 2,955 (Table 2); proxy rs2108166 (r² 0.77) P 5e-7 for the same trait in Liu et al. 2012 (Results) (Table 1; Supplementary Figure 1 (three levels coded 0 to 2))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 143 / 772 / 1589 · Africa 29 / 224 / 408 · The Americas 73 / 151 / 123 · East Asia 6 / 67 / 431 · Europe 22 / 176 / 305 · South Asia 13 / 154 / 322

See this card in the sample report

Limits

What it cannot tell you

This small marker association concerns measured facial geometry in the research sample. It does not reconstruct your face, classify attractiveness or calculate a facial measurement. Only the studied C/T allele pair is interpreted.

A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation (Adhikari et al., 2016)

The same topic

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