DNA Traits · Appearance

Male pattern hair loss, WNT10A marker

How much scalp hair men lose in the usual male pattern, from a receding hairline to a thinning crown.

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Evidence · Replicated

What the research found

In the cited research, the T allele at rs7349332 was associated with more extensive male pattern hair loss in the studied men.

CC: Less balding
CT: Middle
TT: More balding

Slight effect

What the study found

In the study, each copy went with self-reported hair loss pattern on a four step scale from no balding to extensive balding, adjusted for age and ancestry about 0.08 points higher on average.

Men of European ancestry in UK Biobank · 205,327 people · Supplementary Data 3 (rs7349332 row: ALLELE1 T, A1FREQ 0.146, BETA 0.0753, SE 0.0043, P 1.6e-68)Dissection of genetic variation and evidence for pleiotropy in male pattern baldness (Yap et al., 2018)

Evidence: Replicated genome-wide association
Who was studied: Men of European ancestry

The research behind this card was done only in men, so it is part of a report requested as male.

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	CCLess balding	CTMiddle	TTMore balding
All regions2,504 people	72%	25%	3%
Africa661 people	83%	16%	<1%
The Americas347 people	78%	21%	1%
East Asia504 people	63%	32%	5%
Europe503 people	77%	22%	<1%
South Asia489 people	59%	35%	6%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	7%4 of 61 copies read
First farmers6500 to 3000 BC	10%100 of 966 copies read
Bronze Age3000 to 1200 BC	14%129 of 936 copies read
Iron Age and Antiquity1200 BC to AD 600	16%175 of 1,128 copies read
Middle AgesAD 600 to 1500	13%71 of 542 copies read
Today1000 Genomes	12%116 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: No copies
Chagyrskaya Neanderthal: No copies
Denisovan: No copies

Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs7349332

The marker

Gene or region: WNT10A
Marker: rs7349332
Location: Chromosome 2 · GRCh37 219,756,383 · GRCh38 218,891,661
Letters studied: C and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: WNT10A · rs7349332
Location: Chromosome 2 · GRCh37 219,756,383 · GRCh38 218,891,661
Studied allele: T
Published statistic: Pirastu 2017: 0.179 discovery (P 1.1e-19) and 0.221 replication (P 2.9e-18) log-odds per T, MAF 0.148. Yap 2018: 0.075 points per T (P 1.6e-68; joint COJO 0.062, P 2.0e-37). Same signal as rs74333950 (r2 1.0, CEU): Heilmann-Heimbach beta -0.24 per T at that SNP, P 5.7e-15 (Table 1) (Supplementary Data 3 (rs7349332 row: ALLELE1 T, A1FREQ 0.146, BETA 0.0753, SE 0.0043, P 1.6e-68))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1811 / 625 / 68 · Africa 549 / 106 / 6 · The Americas 269 / 73 / 5 · East Asia 317 / 161 / 26 · Europe 389 / 112 / 2 · South Asia 287 / 173 / 29

Limits

What it cannot tell you

Studied in men of European ancestry. One of hundreds of markers that shape male pattern hair loss.

GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk (Pirastu et al., 2017)

The same topic

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