DNA Traits · Appearance
Eyebrow thickness, FOXD1 region marker
How thick and full the eyebrows are.
What the research found
In the cited research, the C allele at rs12651896 was associated with thicker eyebrows.
- TT
- Thinner
- CT
- Middle
- CC
- Thicker
What the study found
In the study, each copy went with eyebrow thickness rating from photos on a three level scale from scarce to dense about 0.08 points higher on average.
- Evidence
- Replicated genome-wide association
- Who was studied
- Han Chinese, Uyghur, Latin American and Dutch European
How common each genotype is
| Region | TTThinner | CTMiddle | CCThicker |
|---|---|---|---|
| All regions2,504 people | 53% | 38% | 9% |
| Africa661 people | 44% | 44% | 12% |
| The Americas347 people | 47% | 42% | 11% |
| East Asia504 people | 66% | 30% | 4% |
| Europe503 people | 49% | 44% | 8% |
| South Asia489 people | 60% | 31% | 10% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- FOXD1 region
- Marker
- rs12651896
- Location
- Chromosome 5 · GRCh37 72,502,029 · GRCh38 73,206,202
- Letters studied
- C and T, with C as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- FOXD1 region · rs12651896
- Location
- Chromosome 5 · GRCh37 72,502,029 · GRCh38 73,206,202
- Studied allele
- C
- Published statistic
- Per C: Han 0.084 (P 1.7e-8, n 2,961), Uyghur 0.064 (P 0.054, n 721), CANDELA 0.08 (P 7.5e-6, n 2,301), Rotterdam 0.05 (P 2.9e-4, n 4,411; frequency printed 0.71); three-cohort meta-analysis P 2.5e-13 (Table 1 and Results). CRISPR editing of the site changed FOXD1 expression (Results, Fig 4) (Table 1 (rs12651896, CANDELA row: frequency 0.32, beta 0.08, P 7.54e-6) and Methods (three point scale))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1322 / 959 / 223 · Africa 288 / 294 / 79 · The Americas 164 / 145 / 38 · East Asia 333 / 150 / 21 · Europe 245 / 220 / 38 · South Asia 292 / 150 / 47
What it cannot tell you
Eyebrows were rated from photos on a three level scale. One of several markers that shape eyebrow thickness.
Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans (Wu et al., 2018)More in Appearance
- Eye pigmentation
- Red hair association
- Blond hair association
- Hair shape
- Hair thickness association
- Skin pigmentation
- Freckling association
- Hair greying association
- Eyebrow thickness association
- Beard density association
- Unibrow association
- Nose bridge breadth association
- Nose wing breadth association
- Nose protrusion association
- Nose tip angle association
- Chin protrusion association
- Earlobe attachment association
- Earlobe size association
- Ear ridge folding association
- Male pattern hair loss
- Male pattern hair loss, HDAC9 marker
- Male pattern hair loss, EBF1 marker
- Male pattern hair loss, WNT10A marker
- Hair lightness, SLC24A4 marker
- Blond hair, TPCN2 marker
- Hair lightness, SLC45A2 marker
- Red hair, ASIP region marker
- Hair lightness, HERC2 marker
- Hair colour, IRF4 marker
- Hair shape, WNT10A marker
- Hair shape, PADI3 marker
- Hair shape, HOXC13 marker
- Hair shape, GATA3 region marker
- Hair shape, FRAS1 marker
- Hair shape, LCE3E marker
- Straight hair, EDAR marker
- Eyebrow thickness, FOXL2 marker
- Shovel-shaped incisors
- Finger length ratio (SMOC1 marker)
- Finger length ratio (LDAH marker)
- Finger length ratio (SALL1 marker)
- Finger length ratio (OLA1 marker)
- Nose root position
- Nose wing breadth (PAX1 marker)
- Earlobe attachment (PAX9 marker)
- Earlobe attachment (KIAA1217 marker)
- Earlobe attachment (MRPS22 marker)
- Fingerprint whorls (ADAMTS9 marker)
- Fingerprint whorls (EVI1 marker)
- Fingerprint whorls (SALL3 marker)
- Green or hazel eyes
- Eye pigmentation (TYR)
- Freckling (TYR)
- Skin pigmentation (OCA2 H615R)
- Freckling (PPARGC1B)
- Freckling (HSPA12A)
- Freckling (BNC2)
- Freckling (EMX2)
- Freckling (EIF6, ASIP region)
- Skin lightness (OCA2 A481T)
- Eye pigmentation (TSPAN10)
- Eye pigmentation (TYRP1)
- Eye pigmentation (SLC24A4)
- Eye pigmentation (SIK1)
- Eye pigmentation (OCA2 exon ten)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.