DNA Traits · Appearance
Hair shape, GATA3 region marker
Whether scalp hair grows straight, wavy or curly.
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Evidence · Replicated
What the research found
In the cited research, the A allele at rs1999874 was associated with curlier scalp hair.
- GG
- Straighter
- AG
- Middle
- AA
- Curlier
Slight effect
What the study found
In the study, each copy went with hair curliness on a three level scale from straight through wavy to curly about 0.06 points higher on average.
Latin American adults (CANDELA cohort) · 6,238 people · Supplementary Table 2 (rs1999874 row, CANDELA column: frequency 0.288, beta 0.0631, SE 0.0137, P 4.4e-6) and Methods (CANDELA three level curliness scale)
- Evidence
- Replicated genome-wide association
- Who was studied
- Primarily European ancestry
1000 Genomes Project
How common each genotype is
| Region | GGStraighter | AGMiddle | AACurlier |
|---|---|---|---|
| All regions2,504 people | 45% | 44% | 11% |
| Africa661 people | 36% | 49% | 15% |
| The Americas347 people | 48% | 42% | 10% |
| East Asia504 people | 64% | 33% | 4% |
| Europe503 people | 42% | 44% | 14% |
| South Asia489 people | 37% | 50% | 13% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
rs1999874
The marker
- Gene or region
- LINC00708 / GATA3 region
- Marker
- rs1999874
- Location
- Chromosome 10 · GRCh37 8,353,101 · GRCh38 8,311,138
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- LINC00708 / GATA3 region · rs1999874
- Location
- Chromosome 10 · GRCh37 8,353,101 · GRCh38 8,311,138
- Studied allele
- A
- Published statistic
- Per A: 0.056 European discovery meta-analysis (P 3.7e-9); replication CANDELA 0.063 (P 4.4e-6), ERF 0.040 (P 0.23), POL 0.042 (P 0.30), US 0.043 (P 0.19); non-Asian meta-analysis 0.058 (P 3.5e-18) (Supplementary Table 2); multiple logistic OR 1.15 (Table 2) (Supplementary Table 2 (rs1999874 row, CANDELA column: frequency 0.288, beta 0.0631, SE 0.0137, P 4.4e-6) and Methods (CANDELA three level curliness scale))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1117 / 1103 / 284 · Africa 237 / 324 / 100 · The Americas 168 / 145 / 34 · East Asia 321 / 165 / 18 · Europe 212 / 223 / 68 · South Asia 179 / 246 / 64
Limits
What it cannot tell you
One of many markers that shape hair curl, with a small effect in the study.
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair (Liu et al., 2018)The same topic
More in Appearance
- Eye pigmentation
- Red hair association
- Blond hair association
- Hair shape
- Hair thickness association
- Skin pigmentation
- Freckling association
- Hair greying association
- Eyebrow thickness association
- Beard density association
- Unibrow association
- Nose bridge breadth association
- Nose wing breadth association
- Nose protrusion association
- Nose tip angle association
- Chin protrusion association
- Earlobe attachment association
- Earlobe size association
- Ear ridge folding association
- Male pattern hair loss
- Male pattern hair loss, HDAC9 marker
- Male pattern hair loss, EBF1 marker
- Male pattern hair loss, WNT10A marker
- Hair lightness, SLC24A4 marker
- Blond hair, TPCN2 marker
- Hair lightness, SLC45A2 marker
- Red hair, ASIP region marker
- Hair lightness, HERC2 marker
- Hair colour, IRF4 marker
- Hair shape, WNT10A marker
- Hair shape, PADI3 marker
- Hair shape, HOXC13 marker
- Hair shape, FRAS1 marker
- Hair shape, LCE3E marker
- Straight hair, EDAR marker
- Eyebrow thickness, FOXD1 region marker
- Eyebrow thickness, FOXL2 marker
- Shovel-shaped incisors
- Finger length ratio (SMOC1 marker)
- Finger length ratio (LDAH marker)
- Finger length ratio (SALL1 marker)
- Finger length ratio (OLA1 marker)
- Nose root position
- Nose wing breadth (PAX1 marker)
- Earlobe attachment (PAX9 marker)
- Earlobe attachment (KIAA1217 marker)
- Earlobe attachment (MRPS22 marker)
- Fingerprint whorls (ADAMTS9 marker)
- Fingerprint whorls (EVI1 marker)
- Fingerprint whorls (SALL3 marker)
- Green or hazel eyes
- Eye pigmentation (TYR)
- Freckling (TYR)
- Skin pigmentation (OCA2 H615R)
- Freckling (PPARGC1B)
- Freckling (HSPA12A)
- Freckling (BNC2)
- Freckling (EMX2)
- Freckling (EIF6, ASIP region)
- Skin lightness (OCA2 A481T)
- Eye pigmentation (TSPAN10)
- Eye pigmentation (TYRP1)
- Eye pigmentation (SLC24A4)
- Eye pigmentation (SIK1)
- Eye pigmentation (OCA2 exon ten)
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