Evidence · Replicated

What the research found

In the cited research, the C allele at rs7096127 was associated with less attached, more free-hanging earlobes.

TT: More attached
CT: Middle
CC: Less attached

Slight effect

Evidence: Multi-cohort genome-wide association with independent replication
Who was studied: European American, Latin American and Han Chinese cohorts rated by experts, replicated in 23andMe research participants of European ancestry

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	TTMore attached	CTMiddle	CCLess attached
All regions2,504 people	36%	47%	17%
Africa661 people	36%	47%	18%
The Americas347 people	21%	54%	24%
East Asia504 people	46%	42%	11%
Europe503 people	34%	48%	18%
South Asia489 people	38%	46%	16%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	57%26 of 46 copies read
First farmers6500 to 3000 BC	35%276 of 784 copies read
Bronze Age3000 to 1200 BC	42%290 of 684 copies read
Iron Age and Antiquity1200 BC to AD 600	43%384 of 900 copies read
Middle AgesAD 600 to 1500	39%205 of 525 copies read
Today1000 Genomes	42%421 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: No copies
Chagyrskaya Neanderthal: No copies
Denisovan: No copies

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs7096127

The marker

Gene or region: KIAA1217 region
Marker: rs7096127
Location: Chromosome 10 · GRCh37 24,506,439 · GRCh38 24,217,510
Letters studied: C and T, with C as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: KIAA1217 region · rs7096127
Location: Chromosome 10 · GRCh37 24,506,439 · GRCh38 24,217,510
Studied allele: C
Published statistic: C allele: rater-scored beta on the 0 (free) to 2 (attached) scale −0.034 (SE 0.019, P 0.077) European American, −0.043 (SE 0.010, P 2.06e-5) Latin American, −0.052 (SE 0.016, P 0.001) Chinese; rater-scored meta-analysis P 2.44e-8; 23andMe self-report OR 0.813 (0.793 to 0.834), P 8.48e-59; all four cohorts P 1.56e-65 (Table 1) (Table 1 (23andMe and rater-scored rows); Methods (23andMe sample of 64,950; 0, 1, 2 coding))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 898 / 1179 / 427 · Africa 235 / 310 / 116 · The Americas 73 / 189 / 85 · East Asia 234 / 214 / 56 · Europe 172 / 241 / 90 · South Asia 184 / 225 / 80

See this card in the sample report

Limits

What it cannot tell you

A single marker, one of dozens that shape earlobe attachment.

Multiethnic GWAS reveals polygenic architecture of earlobe attachment (Shaffer et al., 2017)

The same topic

More in Appearance

Free, once per account

See your own two letters.

Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.

See a sample report