DNA Traits · Appearance
Finger length ratio (SMOC1 marker)
The length of the index finger compared with the ring finger.
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Evidence · Replicated
What the research found
In the cited research, the A allele at rs2332175 was associated with a higher index to ring finger length ratio.
- GG
- Lower ratio
- AG
- Middle
- AA
- Higher ratio
Slight effect
What the study found
In the study, each copy went with index finger length as a percentage of ring finger length, left hand about 0.36 ratio points higher on average.
European ancestry discovery cohorts (ALSPAC, Generation R, QIMR, Raine, Rotterdam Study, TwinsUK) · 14,382 people · Table 2 (rs2332175, discovery row); Supplementary Table S3; Discussion (European-only left-hand analysis, N 14 382)
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European ancestry cohorts from the UK, the Netherlands and Australia; replicated in 23andMe research participants
1000 Genomes Project
How common each genotype is
| Region | GGLower ratio | AGMiddle | AAHigher ratio |
|---|---|---|---|
| All regions2,504 people | 31% | 40% | 29% |
| Africa661 people | 71% | 28% | 2% |
| The Americas347 people | 21% | 47% | 32% |
| East Asia504 people | 5% | 31% | 64% |
| Europe503 people | 20% | 51% | 29% |
| South Asia489 people | 21% | 51% | 28% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
rs2332175
The marker
- Gene or region
- SMOC1
- Marker
- rs2332175
- Location
- Chromosome 14 · GRCh37 70,345,411 · GRCh38 69,878,694
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- SMOC1 · rs2332175
- Location
- Chromosome 14 · GRCh37 70,345,411 · GRCh38 69,878,694
- Studied allele
- A
- Published statistic
- beta 0.360 (SE 0.037) per A allele on 2D:4D x 100, P 3.00e-22, EAF 0.529 (Table 2, European discovery meta-analysis); 23andMe replication beta 0.045 (SE 0.004) on a three-level self-reported finger-length scale, P 6.74e-29, n 75,821 (Table 2); same direction in all six discovery cohorts, heterogeneity P 0.418 (Supplementary Table S3); the lead SNPs at the 12 replicated signals together explain 3.8% of the variance (Results) (Table 2 (rs2332175, discovery row); Supplementary Table S3; Discussion (European-only left-hand analysis, N 14 382))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 773 / 1005 / 726 · Africa 468 / 183 / 10 · The Americas 73 / 162 / 112 · East Asia 26 / 155 / 323 · Europe 102 / 255 / 146 · South Asia 104 / 250 / 135
Limits
What it cannot tell you
A single marker, one of many that shape finger proportions. Measured on the left hand.
Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero (Warrington et al., 2018)The same topic
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