Evidence · Not yet replicated

What the research found

In the cited research, the A allele at rs2045323 was associated with less nose protrusion in the studied cohort.

GG: More forward
AG: Middle
AA: Less forward

Slight effect

Evidence: Discovery GWAS of quantitative facial geometry
Who was studied: Admixed Latin American CANDELA participants from Brazil, Chile, Colombia, Mexico and Peru

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	GGMore forward	AGMiddle	AALess forward
All regions2,504 people	74%	23%	4%
Africa661 people	94%	6%	Not seen
The Americas347 people	57%	32%	11%
East Asia504 people	64%	30%	5%
Europe503 people	82%	18%	<1%
South Asia489 people	59%	36%	5%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	11%5 of 44 copies read
First farmers6500 to 3000 BC	10%49 of 498 copies read
Bronze Age3000 to 1200 BC	9%29 of 341 copies read
Iron Age and Antiquity1200 BC to AD 600	8%41 of 529 copies read
Middle AgesAD 600 to 1500	11%49 of 429 copies read
Today1000 Genomes	9%94 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: No copies
Chagyrskaya Neanderthal: No copies
Denisovan: No copies

Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs2045323

The marker

Gene or region: DCHS2 region
Marker: rs2045323
Location: Chromosome 4 · GRCh37 154,831,899 · GRCh38 153,910,747
Letters studied: A and G, with A as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: DCHS2 region · rs2045323
Location: Chromosome 4 · GRCh37 154,831,899 · GRCh38 153,910,747
Studied allele: A
Published statistic: effect -5.9e-4 per A allele on a Procrustes-adjusted 3D landmark measure, P 1e-8, 0.95% of variance, n 2,955 (Table 2) (Table 2)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1845 / 568 / 91 · Africa 623 / 38 / 0 · The Americas 199 / 110 / 38 · East Asia 325 / 152 / 27 · Europe 410 / 92 / 1 · South Asia 288 / 176 / 25

See this card in the sample report

Limits

What it cannot tell you

This small marker association concerns measured facial geometry in the research sample. It does not reconstruct your face, classify attractiveness or calculate a facial measurement. Nose protrusion and nose tip angle share the same DCHS2 marker and are not independent genetic signals. Only the studied A/G allele pair is interpreted.

A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation (Adhikari et al., 2016)

The same topic

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