DNA Traits · Appearance

Finger length ratio (OLA1 marker)

The length of the index finger compared with the ring finger.

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Evidence · Replicated

What the research found

In the cited research, the A allele at rs12474669 was associated with a higher index to ring finger length ratio.

GG: Lower ratio
AG: Middle
AA: Higher ratio

Slight effect

What the study found

In the study, each copy went with index finger length as a percentage of ring finger length, left hand about 0.42 ratio points higher on average.

European ancestry discovery cohorts with data for this SNP (ALSPAC, Generation R, QIMR, Rotterdam Study, TwinsUK; none from Raine) · Table 2 (rs12474669, discovery row); Supplementary Table S3 (no Raine data for this SNP)

Evidence: Genome-wide association with independent replication
Who was studied: European ancestry cohorts from the UK, the Netherlands and Australia; replicated in 23andMe research participants

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	GGLower ratio	AGMiddle	AAHigher ratio
All regions2,504 people	79%	20%	2%
Africa661 people	99%	1%	Not seen
The Americas347 people	73%	25%	2%
East Asia504 people	63%	31%	5%
Europe503 people	72%	27%	<1%
South Asia489 people	78%	21%	<1%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

rs12474669

The marker

Gene or region: OLA1 region
Marker: rs12474669
Location: Chromosome 2 · GRCh37 175,134,232 · GRCh38 174,269,504
Letters studied: A and G, with A as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: OLA1 region · rs12474669
Location: Chromosome 2 · GRCh37 175,134,232 · GRCh38 174,269,504
Studied allele: A
Published statistic: beta 0.417 (SE 0.054) per A allele on 2D:4D x 100, P 1.51e-14, EAF 0.139 (Table 2, European discovery meta-analysis); 23andMe replication beta 0.043 (SE 0.006) on a three-level self-reported finger-length scale, P 1.92e-13, n 75,821 (Table 2); same direction in the five discovery cohorts with data (Raine missing), heterogeneity P 0.447 (Supplementary Table S3); the lead SNPs at the 12 replicated signals together explain 3.8% of the variance (Results) (Table 2 (rs12474669, discovery row); Supplementary Table S3 (no Raine data for this SNP))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1970 / 494 / 40 · Africa 653 / 8 / 0 · The Americas 252 / 88 / 7 · East Asia 320 / 158 / 26 · Europe 364 / 136 / 3 · South Asia 381 / 104 / 4

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Limits

What it cannot tell you

A single marker, one of many that shape finger proportions. Measured on the left hand.

Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero (Warrington et al., 2018)

The same topic

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