DNA Traits · Appearance

Male pattern hair loss, EBF1 marker

How much scalp hair men lose in the usual male pattern, from a receding hairline to a thinning crown.

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Evidence · Replicated

What the research found

In the cited research, the A allele at rs17643057 was associated with more extensive male pattern hair loss in the studied men.

GG: Less balding
AG: Middle
AA: More balding

Slight effect

What the study found

In the study, each copy went with self-reported hair loss pattern on a four step scale from no balding to extensive balding, adjusted for age and ancestry about 0.1 points higher on average.

Men of European ancestry in UK Biobank · 205,327 people · Supplementary Data 3 (rs17643057 row: ALLELE1 G, A1FREQ 0.394, BETA -0.1007, SE 0.0031, P 5.0e-225)Dissection of genetic variation and evidence for pleiotropy in male pattern baldness (Yap et al., 2018)

Evidence: Replicated genome-wide association
Who was studied: Men of European ancestry

The research behind this card was done only in men, so it is part of a report requested as male.

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	GGLess balding	AGMiddle	AAMore balding
All regions2,504 people	13%	39%	48%
Africa661 people	2%	24%	74%
The Americas347 people	9%	47%	44%
East Asia504 people	7%	42%	51%
Europe503 people	14%	47%	40%
South Asia489 people	37%	44%	19%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

rs17643057

The marker

Gene or region: EBF1
Marker: rs17643057
Location: Chromosome 5 · GRCh37 158,274,491 · GRCh38 158,847,483
Letters studied: A and G, with A as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: EBF1 · rs17643057
Location: Chromosome 5 · GRCh37 158,274,491 · GRCh38 158,847,483
Studied allele: A
Published statistic: Heilmann-Heimbach 2017 Table 1: EA/OA G/A, EAF 0.40, beta -0.21 (s.e.m. 0.02) log-odds, P 2.6e-25, 10,846 early-onset cases and 11,672 controls in eight cohorts. Pirastu 2017: -0.190 discovery (P 8.0e-40) and -0.177 replication (P 6.8e-25) log-odds per G. Yap 2018: -0.101 points per G (SE 0.003), P 5.0e-225, n 205,327; the plain figure is that beta flipped to A (Supplementary Data 3 (rs17643057 row: ALLELE1 G, A1FREQ 0.394, BETA -0.1007, SE 0.0031, P 5.0e-225))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 333 / 981 / 1190 · Africa 15 / 158 / 488 · The Americas 32 / 163 / 152 · East Asia 34 / 211 / 259 · Europe 70 / 234 / 199 · South Asia 182 / 215 / 92

Limits

What it cannot tell you

Studied in men of European ancestry. One of hundreds of markers that shape male pattern hair loss.

Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness (Heilmann-Heimbach et al., 2017)

The same topic

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