DNA Traits · Appearance

Eyebrow thickness, FOXL2 marker

How thick and full the eyebrows are.

See a sample report

Free, once per account. Your own private report.

Evidence · Not yet replicated

What the research found

In the cited research, the G allele at rs112458845 was associated with thinner eyebrows in the studied Latin American men.

AA: Thicker
AG: Middle
GG: Thinner

Modest effect

What the study found

In the study, each copy went with eyebrow thickness rating from photos on a three level scale (low, medium, high) about 0.13 points lower on average.

Latin American men (CANDELA) · 2,301 people · Wu 2018 Table 1 (rs112458845, CANDELA row: frequency 0.27, beta -0.127, P 4.95e-11)

Evidence: Discovery genome-wide association, not replicated in other ancestries
Who was studied: Latin American men

The research behind this card was done only in men, so it is part of a report requested as male.

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	AAThicker	AGMiddle	GGThinner
All regions2,504 people	76%	21%	4%
Africa661 people	52%	39%	9%
The Americas347 people	57%	33%	10%
East Asia504 people	93%	7%	Not seen
Europe503 people	>99%	<1%	Not seen
South Asia489 people	77%	22%	1%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

rs112458845

The marker

Gene or region: FOXL2 / FOXL2NB region
Marker: rs112458845
Location: Chromosome 3 · GRCh37 138,675,741 · GRCh38 138,956,899
Letters studied: A and G, with G as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: FOXL2 / FOXL2NB region · rs112458845
Location: Chromosome 3 · GRCh37 138,675,741 · GRCh38 138,956,899
Studied allele: G
Published statistic: Adhikari 2016: P 4e-10 (Table 1); within-country meta-analysis P 1.1e-10, random effects P 5.6e-4 (Supplementary Table 4); effect size only plotted (Figure 2g). Wu 2018 per G: Han -0.009 (P 0.73, frequency 0.065), Uyghur 0.056 (P 0.49, 0.032), Rotterdam 0.089 (P 0.37, 0.00); heterogeneity I2 82% (Table 1 and Results) (Wu 2018 Table 1 (rs112458845, CANDELA row: frequency 0.27, beta -0.127, P 4.95e-11))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1892 / 515 / 97 · Africa 347 / 256 / 58 · The Americas 198 / 116 / 33 · East Asia 469 / 35 / 0 · Europe 501 / 2 / 0 · South Asia 377 / 106 / 6

Limits

What it cannot tell you

Seen only in Latin American men; it did not replicate in Han Chinese, Uyghurs or Dutch Europeans, and the G letter is almost absent in Europe.

Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans (Wu et al., 2018)

The same topic

More in Appearance

Free, once per account

See your own two letters.

Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.

See a sample report