Evidence · Replicated

What the research found

In the cited research, the G allele at rs1345417 was associated with thicker eyebrows.

CC: Thinner
CG: Middle
GG: Thicker

Slight effect

What the study found

In the study, each copy went with eyebrow thickness rating from photos, on a three level scale (scarce, normal, dense) about 0.04 points higher on average.

Dutch European adults (Rotterdam Study) · 4,411 people · Table 1 (rs1345417, RS row) and Methods (ordinal phenotyping)

Evidence: Replicated genome-wide association and regulatory experiments
Who was studied: Han Chinese, Uyghur, admixed Latin American and Dutch European cohorts

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	CCThinner	CGMiddle	GGThicker
All regions2,504 people	22%	45%	33%
Africa661 people	13%	44%	44%
The Americas347 people	25%	46%	29%
East Asia504 people	50%	41%	9%
Europe503 people	13%	49%	38%
South Asia489 people	13%	47%	40%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	70%68 of 97 copies read
First farmers6500 to 3000 BC	58%553 of 956 copies read
Bronze Age3000 to 1200 BC	62%567 of 921 copies read
Iron Age and Antiquity1200 BC to AD 600	58%769 of 1,326 copies read
Middle AgesAD 600 to 1500	54%584 of 1,076 copies read
Today1000 Genomes	63%629 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: Not read
Vindija Neanderthal: Not read
Chagyrskaya Neanderthal: 2 copies
Denisovan: Not read

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs1345417

The marker

Gene or region: SOX2 region
Marker: rs1345417
Location: Chromosome 3 · GRCh37 181,511,951 · GRCh38 181,794,163
Letters studied: C and G, with G as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: SOX2 region · rs1345417
Location: Chromosome 3 · GRCh37 181,511,951 · GRCh38 181,794,163
Studied allele: G
Published statistic: beta per G allele: 0.092 Han Chinese discovery (n 2961, P 6.51e-10), 0.105 Uyghur (n 721, P 3.78e-4), 0.098 CANDELA men (n 2301, P 1.04e-7), 0.04 Rotterdam Study (n 4411, P 4.03e-3) (Table 1); meta-analysis of the first three P 5.20e-19 fixed effect (S3 Table) (Table 1 (rs1345417, RS row) and Methods (ordinal phenotyping))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 551 / 1133 / 820 · Africa 84 / 288 / 289 · The Americas 86 / 161 / 100 · East Asia 252 / 207 / 45 · Europe 66 / 245 / 192 · South Asia 63 / 232 / 194

See this card in the sample report

Limits

What it cannot tell you

Eyebrow density depends on many genes and changes with age, hormones and grooming. This marker is not a prediction of your eyebrow shape or density. Only the studied C/G allele pair is interpreted.

Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans (Wu et al., 2018)

The same topic

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