DNA Traits · Appearance

Hair shape, PADI3 marker

Whether scalp hair grows straight, wavy or curly.

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Evidence · Replicated

What the research found

In the cited research, the G allele at rs11203346 was associated with straighter scalp hair.

AA: Curlier
AG: Middle
GG: Straighter

Slight effect

What the study found

In the study, each copy went with hair curliness on a three level scale from straight through wavy to curly about 0.06 points lower on average.

Latin American adults (CANDELA cohort) · 6,238 people · Supplementary Table 2 (rs11203346 row, CANDELA column: frequency 0.084, beta -0.0600, SE 0.0224, P 7.4e-3) and Methods (CANDELA three level curliness scale)

Evidence: Replicated genome-wide association
Who was studied: Primarily European ancestry

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	AACurlier	AGMiddle	GGStraighter
All regions2,504 people	84%	15%	1%
Africa661 people	82%	16%	1%
The Americas347 people	79%	20%	1%
East Asia504 people	>99%	<1%	Not seen
Europe503 people	67%	30%	3%
South Asia489 people	92%	8%	<1%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

rs11203346

The marker

Gene or region: PADI3
Marker: rs11203346
Location: Chromosome 1 · GRCh37 17,600,822 · GRCh38 17,274,327
Letters studied: A and G, with G as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: PADI3 · rs11203346
Location: Chromosome 1 · GRCh37 17,600,822 · GRCh38 17,274,327
Studied allele: G
Published statistic: Per G: -0.067 European discovery meta-analysis (QIMR, TwinsUK, RS; P 4.6e-8, n 16,763); replication ERF -0.170 (P 3.4e-5), CANDELA -0.060 (P 7.4e-3), POL -0.079 (P 0.17), US -0.008 (P 0.86); non-Asian meta-analysis -0.070 (P 9.2e-17) (Supplementary Table 2); multiple logistic OR 0.79 (Table 2) (Supplementary Table 2 (rs11203346 row, CANDELA column: frequency 0.084, beta -0.0600, SE 0.0224, P 7.4e-3) and Methods (CANDELA three level curliness scale))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 2108 / 369 / 27 · Africa 543 / 109 / 9 · The Americas 274 / 69 / 4 · East Asia 503 / 1 / 0 · Europe 339 / 151 / 13 · South Asia 449 / 39 / 1

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Limits

What it cannot tell you

One of many markers that shape hair curl, with a small effect in the study.

Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair (Liu et al., 2018)

The same topic

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